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Smell and Taste Receptors in the Heart

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Smell and taste receptors normally found in the nose and mouth have been found in the human heart. Dr Simon Foster made the discovery, published in The Journal of the Federation of American Societies for Experimental Biology, as part of his PhD at the University of Queensland.

“Dr Foster was able to show that around 12 taste receptors, particularly those that respond to bitter compounds, were expressed in human hearts,” said team leader Prof Walter Thomas. “This is quite remarkable, as the human genome only has 25 of these bitter taste receptors, and we wanted to find out why half of them were located in the heart.

“When we activated one of the taste receptors with a specific chemical that we all taste as bitter, the contractile function of the heart was almost completely inhibited. While the underlying physiology behind this phenomenon remains unclear, this is now a major area of ongoing investigation.”

The research team’s primary focus is on how the heart grows normally as well as abnormally in disease.

“After hypertension or a heart attack, the heart frequently undergoes compensatory growth in order to maintain the circulation of blood around the body,” Thomas said. “But a common end result of this compensatory growth is eventual heart failure.

“We were looking at all the genes that are regulated in the heart in this growth phase. We...

The full text of this article can be purchased from Informit.