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Study Shows How Chinese Medicine Kills Cancer Cells

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Researchers at The University of Adelaide have shown how a complex mix of plant compounds derived from a traditional Chinese medicine can kill cancer cells.

Compound kushen injection (CKI) is approved for use in China to treat various cancer tumours, usually as an adjunct to western chemotherapy. How it works has not been known.

The study, published in Oncotarget (http://tinyurl.com/j2eovrm), is one of the first to characterise the molecular action of a traditional Chinese medicine rather than breaking it down to its constituent parts.

“If we broke down and tested the components of many traditional Chinese medicines, we would find that individual compounds don’t have much activity on their own,” says study leader Prof David Adelson of the Zhendong Australia–China Centre for the Molecular Basis of Traditional Chinese Medicine. “It’s the combination of compounds which can be effective, and potentially means few side-effects as well.

“This is one of the first studies to show the molecular mode of action of a complex mixture of plant-based compounds – in this case extracts from the roots of two medicinal herbs, Kushen and Baituling.”
 


The researchers used high-throughput next generation sequencing technologies to identify genes and biological pathways targeted by...

The full text of this article can be purchased from Informit.