Australasian Science: Australia's authority on science since 1938

Faulty Gene Linked to Depression and Cardiovascular Disease

The full text of this article can be purchased from Informit.

Researchers may have discovered a new target in the fight against depression: a faulty gene that is linked to cardiovascular and metabolic conditions.

The findings – published in Neuroscience & Biobehavioral Reviews ( – have supported a number of theories about the underlying genetic causes of depression, and have highlighted one gene that until now has gone under the radar in relation to mood disorders.

“Depression is much more complex than most people think, and it includes dysfunction at multiple biological levels, from genes to brain regions and blood circulating through the body,” says lead author Prof Bernhard Baune of The University of Adelaide.

“The state of depression can also change over time. It goes through various phases and it may present with a large range of symptoms,” he explained.

“In those circumstances, it shouldn’t be surprising that, while there’s a growing body of research investigating the underlying genetics of depression, so far there have been inconsistent findings in various studies throughout the world.”

The team examined and re-analysed research covering 16 brain regions and five cell types from the peripheral nervous system. Across the body of work, they identified 57 differently expressed genes in the...

The full text of this article can be purchased from Informit.