Potential antibiotic alternative to treat infection without resistance
Researchers at the University of Michigan have found a potential alternative to conventional antibiotics that could fight infection with a reduced risk of antibiotic resistance.
By using high-throughput screening of a library of small molecules from the Center for Chemical Genomics at the University of Michigan's Life Sciences Institute, the team identified a class of compounds that significantly reduced the spread and severity of group A Streptococcus (GAS) bacteria in mice. Their work suggests that the compounds might have therapeutic value in the treatment of strep and similar infections in humans.
"The widespread occurrence of antibiotic resistance among human pathogens is a major public health problem," said Prof David Ginsburg of the University of Michigan Medical School.
Work on this project is continuing, including the preparation of new compounds with improved potency and the filing of patents.
Current antibiotics interfere with critical biological processes in the pathogen to kill it or stop its growth. But at the same time, stronger strains of the harmful bacteria can sometimes resist the treatment and flourish.
An alternate approach is to suppress the virulence of the infection but still allow the bacteria to grow, which means there is no strong selection for strains that are resistant to antibiotics. In a similar experiment at Harvard University, an anti-virulence strategy was successful in protecting mice from cholera.
About 700 million people have symptomatic GAS infections around the world each year, and the infection can be fatal. Most doctors prescribe penicillin. The newly identified compounds could work with conventional antibiotics and result in more effective treatment.
The research results were published online in the Proceedings of the National Academy of Sciences.
