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Hitting the Brakes When Cells Get out of Control

B cells

These figures show normal B cells (left) and those from SPPL2A mutant mice (right) with CD74 staining in green and nuclear staining in blue. In SPPL2A mutant mice, CD74 cannot be broken down so it accumulates around the nucleus. 

By Hsei-Di Law

By creating a “traffic jam” in the transport pathway of B cells, researchers have found a potential drug target to slow the proliferation of cancerous cells.

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