Australasian Science: Australia's authority on science since 1938

Resistant Bacteria Rising Rapidly

A national study published by the federal Department of Health has confirmed that antibiotic-resistant strains of disease-causing bacteria are steadily on the rise in Australia.

“Emerging resistance in common pathogens is a worldwide phenomenon, and this is a significant issue for healthcare practitioners and their patients,” says the lead author of the report, Prof John Turnidge of the University of Adelaide.

“Compared with many other countries in our region, antibiotic resistance rates in Australia are still relatively low. However, there are some worrying trends in the latest data which, for example, show a doubling of resistance among E. coli against some important reserve antibiotics.

“Importantly, this study looked at samples from patients who were not hospitalised, so these are rates of antibiotic resistance out there in the general Australian population,” Turnidge says.

Samples were collected at 29 health centres around Australia in 2012 from non-hospitalised patients with urinary infections. The study tested 2025 species of Escherichia coli (E. coli), 538 of Klebsiella and 239 of Enterobacter, and the results were compared with the previous community study in 2008.

Overall, multi-resistance to three classes of antibiotics was found in 7.6% of E. coli samples compared with 4.5% 4 years earlier, 5.1% of Klebsiella (compared with 4.4%) and 5.4% of Enterobacter (4.2% in 2008).

While common strains of E. coli can cause urinary tract and other localised infections, some strains of E. coli can invade the bloodstream and cause septicaemia, which can result in up to 20% mortality.

“E. coli is the species of most concern to us because it’s showing a noticeable increase in resistance to one of the most commonly used antibiotics – its resistance to amoxycillin is now at 44%,” Turnidge says.

“E. coli’s resistance is also increasing to one of our last-line oral antibiotics, ciprofloxacin, which has risen from 4.2% to 6.9% between 2008 and 2012. This is despite the antibiotic being restricted to needy cases in the community.

“We’re now seeing some E. coli resistance to reserve intravenous antibiotics, which practitioners would normally only use once the patient is sick enough to admit to hospital, with blood poisoning for example.”