Australasian Science: Australia's authority on science since 1938

The Rogue Molecule That Triggers Autoimmunity

An electron microscope image of mitochondria undergoing herniation. On the botto

An electron microscope image of mitochondria undergoing herniation. On the bottom mitochondria (red) there are two membranes (lines) surrounding it on the left side, while there is only one membrane surrounding the mtDNA (green) on the right. Credit: Dr Benjamin Padman/Dr Kate McArthur

By Benjamin Kile, Kate McArthur & Tahnee Saunders

Mitochondrial DNA has been implicated in diseases such as arthritis, but how it escapes from inside the mitochondria and triggers these disorders has remained a mystery. Now Australian scientists have captured video evidence of mtDNA escaping for the first time.

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