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A One-Shot Flu Jab for Life

A research team led by the University of Melbourne has determined how flu-killing CD8+ T cells memorise distinct strains of influenza, opening the way for the development of a one-shot flu jab for life.

The research began during the first outbreak of the avian-derived H7N9 virus in China in 2013, which saw 99% of people infected hospitalised and a 30% mortality rate. Patient zero was an elderly man who caught the virus from a chicken his wife asked him to buy at the local live bird market.

“We’d never seen anything like H7N9,” said A/Prof Katherine Kedzierska. “The virus was infecting more people rapidly, and nobody had immunity. Thankfully, we did manage to contain the virus but we knew we had come face-to-face with a potential pandemic that could kill millions of people around the world if the virus became able to spread between humans,” she said.

“After collecting samples from infected patients we found that people who couldn’t make these T cell flu assassins were dying. These findings led to the potential of moving from vaccines for specific influenza strains toward developing a protection, which is based on T cells,” she said.

“From the 30% mortality rate in China we knew the clock was ticking on the situation. Had the contagion spread broken out globally, we’re talking about a history-altering event on the Spanish Flu scale. As it turns out, boosting the T cell adaptive memory capacity is our way in,” Kedzierska said.

“Our extraordinary breakthrough could lead to the development of a vaccine component that can protect against all new influenza viruses, with the potential for future development of a one-off universal flu vaccine shot,” she said.

“This work will also help clinicians to make early predictions of how well a patient’s immune system will respond to viruses so they can manage early interventions such as artificial ventilation more effectively, particularly in cases where the patient is at risk of dying.”

The research was published in Nature Communications.