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Hallucinations Associated with Brain Hyperactivity in People with Age-Related Blindness

New research from The University of Queensland has revealed that visual hallucinations in people with macular degeneration are associated with abnormally heightened activity in the visual cortex of the brain. The findings, published in Current Biology (, could improve the diagnosis of such hallucinations.

Macular degeneration is a retinal eye disease that causes progressive deterioration of the central region of the retina, leading to visual loss in the centre of the field of vision while peripheral vision usually remains unaffected. Many people who develop macular degeneration also develop Charles Bonnet Syndrome, in which they experience hallucinations as the brain adjusts to significant vision loss. The hallucinations can be simple geometric patterns, or much more complex scenes involving animals, people and places.

Why some people with macular degeneration experience hallucinations while others do not has remained unclear, but there have been suggestions that the excitability of some visual regions of the brain could play a role. To address this, the research team measured brain electrical activity while stimulating the peripheral visual fields of study participants.

“Their task was to look at letters appearing on the screen in their periphery, and we flashed checkerboards at unique frequencies on the screen,” said Dr David Painter, the paper’s first author. “We found that these checkerboards produced unique oscillations in visual areas of the brain that we can measure using mathematical techniques. The main finding is that when we drive activity in the visual system of people with macular degeneration who report experiencing hallucinations, there is a huge visual response compared with participants who have the same visual loss but don’t have the hallucinations.”

While people with macular degeneration who experience hallucinations demonstrated visual hyperexcitability, the translation of this hyperexcitability into hallucinations was not automatic; it depends on external triggers that remain unknown. “During the testing, none of our participants experienced hallucinations, so it’s not that heightened excitability of the brain produces hallucinations – it’s some other factor,” Painter said.

“Sometimes people have these hallucinations when they’re in periods of low sensory stimulation, such as in low light or periods of inactivity, but for others it can be triggered by things such as car rides or television. What our results say is that the brains of those reporting hallucinations are more excitable, but it still remains unclear how that excitability is then translated into hallucinations.”

The findings could help reduce misdiagnosis of hallucinations in people with MD. “When people get older and they start having these unusual experiences, they are often worried that something is wrong with them, such as dementia,” Painter said. “Doctors sometimes don’t recognise the disease either, and therefore can give people inappropriate medication, but our method potentially allows us to detect people who might have Charles Bonnet Syndrome.

“Once people realise it’s not a brain disorder as such, they tend to have a neutral or even positive experience of their hallucinations. Unlike the hallucinations in people with schizophrenia, for example, individuals with Charles Bonnet Syndrome are aware their hallucinations aren’t real.”