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How Hepatitis Escapes the Immune System

Credit: Frederic Sierro

The liver’s unusual cellular architecture makes blood flow slower than in other organs. Perforations of the lining of the blood vessels within the liver allow a unique contact between the circulating blood cells (red) and the liver cells (green), and explains why activated T cells (blue) are efficiently retained in the liver. Credit: Frederic Sierro

By Patrick Bertolino and David Bowen

Recent discoveries about the unusual behaviour of immune cells in the liver could open the way to new strategies for transplantation and the treatment of viral hepatitis.

Patrick Bertolino and David Bowen are co-heads of the Liver Immunology group at the Centenary Institute in Sydney.

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